Combination Interactive Effects of Gongronema latifolium Leaves and Picralima nitida Seeds Extracts on Glucose Tolerance

This study evaluated the combination interactive effects of G. latifolium leaves and P. nitida seed extracts using a metabolic glucose tolerance test. The plant samples were extracted separately cold maceration their acute toxicities determined. Dose-response tolerant tests both plants done 2 g/kg load monitored over 0 – 1h. A 41% effect isobologram was used to determine needed dose combinations according principle Loewe’s additivity model. pairs combined indices calculated nature interaction. ED41 (GL) (PN) 180 mg/kg 254 respectively. percentage reductions GL:PN (50:160); (100:90); (150:30) 48.23, 50.76 42.99 % Their index be 0.91, 0.91 0.95 respectively - an indication synergistic Findings from this validate use seeds in folkloric medicine. However, combining latifolium: ratios 50:160, 100:90 150:30 gave best with outcome.